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Clinical 1: Efficacy of Supervised Mouth Rinsing and Flossing on Plaque and Gingivitis1
OBJECTIVE:
To evaluate the efficacy of twice-daily rinsing with Listerine® Antiseptic and brushing vs. flossing and brushing under once-daily supervision for the prevention and reduction of plaque and gingivitis.
STUDY DESIGN
- Single center, randomized, supervised, examiner blind, controlled clinical trial conducted at ADA-Qualified site.
- Following a complete prophylaxis, subjects were examined for oral soft tissue status, plaque, gingivitis, and gingival bleeding at Baseline, 4 weeks, and 12 weeks.
- If assigned to a flossing group, subjects were given flossing instructions and demonstrated competency.
- Product use was supervised once daily in person on weekdays with second daily and weekend product use unsupervised.
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STUDY PARTICIPANTS
- 156 subjects (18 years of age and older) with mild-to-severe gingivitis and no severe periodontitis, with no entry criteria on Modified Gingival Index (MGI)/plaque, but must have minimum of 10 gingival bleeding sites.
- The efficacy outcomes included interproximal and whole-mouth mean modified Turesky Plaque Index (TPI), mean MGI, gingival bleeding, bleeding on probing depth, and probing depth.
ADDITIONAL RESULTS
1. Mean Turesky Plaque Index (TPI)* P<0.001; comparing each investigational product vs. Control. Clinical 1 control = Brush + 5% Hydroalcohol Mouth Rinse.
Reference: 1. Bosma, M. L., McGuire, J. A., Sunkara, A., Sullivan, P., Yoder, A., Milleman, J., & Milleman, K. (2022). Efficacy of Flossing and Mouthrinsing Regimens on Plaque and Gingivitis: A randomized clinical trial. American Dental Hygienists' Association, 96(3), 8-20.